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Shyh-Dar Li Inventions, Patents and Patent Applications
Patent number: 8591877. Abstract: In one aspect, there is provided a compound comprising an acetylated carboxymethylcellulose (CMC-Ac) covalently linked to: at least one poly (ethylene glycol) (PEG), and at least one hydrophobic drug. In another aspect, a self-assembling nanoparticle composition comprising such compounds is …
Interplay between the linker and polymer molecular weight …
E-mail: [email protected]. Abstract. Poorly water-soluble small hydrophobic compounds can be conjugated to a hydrophilic polymer such as methoxypolyethylene glycol (mPEG) to form amphiphilic prodrugs that can self-assemble into nanoparticles (NPs) with increased aqueous solubility, prolonged circulation, and improved delivery. ...
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Gehring L.P. was founded in 1976 in Farmington Hills, Michigan, which is a suburb of Detroit. Our 50,000 square foot facility offers a full-service machine tool operation, …
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Development of a Child-Friendly Oral Drug Formulation …
Nojoud Al Fayez 1, Roland Böttger 1, Sreemoyee Ghosh 1, Yushi Nakajima 1, Po-Han Chao 1, Elham Rouhollahi 1, Anne Nguyen 1, Pieter R Cullis 2, Dominik Witzigmann 2, Shyh-Dar Li 3 Affiliations
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Protamine-mediated efficient transcellular and transmucosal …
Protamine was shown to promote tubulation and rearrangement of cellular actin, leading to enhanced intracellular delivery of proteins compared to poly (arginine) 8 (R8). While the R8-mediated delivery resulted in significant lysosomal accumulation of the cargo, protamine directed the proteins to the nuclei with little lysosomal uptake.
Hepatocyte-targeted delivery of imiquimod reduces …
Electronic address: [email protected]. PMID: 36058352 DOI: 10.1016/j.jconrel.2022.08.058 Abstract Hepatitis B virus (HBV) can rapidly replicate in the hepatocytes after transmission, leading to chronic hepatitis, liver cirrhosis and eventually hepatocellular carcinoma. Interferon-α (IFN-α) is included in the standard treatment for …
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About Dr. Shyh-Dar Li | Laboratory of Targeted Drug …
Dr. Shyh-Dar Li, BSc(Pharm), PhD Angiotech Professor in Drug Delivery Profile Dr. Shyh-Dar Li received a BSc in Pharmacy from National Taiwan University and a PhD in Pharmaceutical Sciences from University of North Carolina at Chapel Hill. After completing his postdoctoral training at University of California, San Diego, he joined Ontario Institute …
Technical rief 2˜HYDROXYETHYL ETHACRYLATE
where it has the additional advantage of being rigid and easy to shape with grinding tools when it is dry and then becomes flexible when it absorbs water. GRADES OFFERED BY POLYSCIENCES While HEMA is available in a variety of industrial grades useful for coatings, adhesives and plastics, well-characterized, higher purity ...
Utilization of click chemistry to study the effect of …
1 Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia V6 T 1Z3, Canada. [email protected]. PMID: 32700691 DOI: 10.1039/d0bm00711k Abstract Many small-molecule drugs exhibit poor aqueous solubility, and various approaches have been developed to improve their solubility and delivery. ...
Shyh-Dar Li (0000-0002-1763-2667)
The mechanism of Hepatocyte-Targeting and safety profile of Phospholipid-Free small unilamellar vesicles. International journal of pharmaceutics. | Journal article. DOI: 10.1016/j.ijpharm.2022.122269. PMID: 36220590. Contributors : Al Fayez N; Roland Böttger; Brown J; Rouhollahi E; Li SD. Show more detail. Source : Shyh-Dar Li.
Plasma-induced graft copolymerization of HEMA onto
Experimental results obtained by ESCA high resolution curve fitting spectra indicated that the amount of bisamino PEO of different molecular weights immobilized onto SR surfaces were similar, which showed that the influence of the length of molecular chains (-C-C-O-) on the reactivity of terminal amino group is negligible.
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shyh dar ball mill machine catalyteceudetissue polyester machine grinder in benin. Ball Mill Ball Mills Ball Mill Machine Ball Grinding Mill Energy Saving Ball Mill Ball mill an energy saving grinding device is widely used in mineral processing building materials and chemical industriBall Mill machine grinds material by rotating a cylinder with steel grinding balls …
Preclinical pharmacokinetic, biodistribution, and anti …
Mark J Ernsting 1, Wei-Lun Tang, Noah W MacCallum, Shyh-Dar Li. Affiliation 1 Drug Delivery and Formulation Group, Medicinal Chemistry Platform, Ontario Institute for Cancer Research, Toronto, Ontario, Canada. PMID: 22079003 DOI: 10.1016/j ...
Videos | Laboratory of Targeted Drug Delivery and …
START GRAD SCHOOL STRONG: what I wish I knew | advice for first year phd students in STEM research A safer and effective pain killer Targeted Chemotherapy of Cancer using Cellax Nanoparticles Dr. Shyh-Dar Li gave a talk in LRD 2019 Dr. Shyh-Dar Li speaks about the SALT technique […]
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People | Laboratory of Targeted Drug Delivery and …
Principal Investigator Shyh-Dar Li, BSc (Pharm), PhD Angiotech Professor in Drug Delivery Phone: 604-827-0675 Email: [email protected] Dr. Shyh-Dar Li received a BSc in Pharmacy from National Taiwan University and a PhD in Pharmaceutical Sciences from University of North Carolina at Chapel Hill. After completing his postdoctoral training at …
An efficient and low immunostimulatory nanoparticle
We have developed a nanoparticle formulation [liposomes-protamine-hyaluronic acid nanoparticle (LPH-NP)] for systemically delivering siRNA into the tumor. The LPH-NP was prepared in a self-assembling process. Briefly, protamine and a mixture of siRNA and hyaluronic acid were mixed to prepare a negat …
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Shyh-Dar Shyur and Kuender-Der Yang performed the experiments, authored or reviewed drafts of the paper, approved the final draft. Jian-Han Chen conceived and designed the …
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